α-Lipoic acid can inhibit the activation of nuclear factor κB induced by hydrogen peroxide, tumor necrosis factor α, and advanced glycosylated end products to protect the function of vascular endothelial cells, increase the blood flow of neurotrophic vessels, promote nerve myelin formation and axon regeneration, repair damaged nerves, improve nerve conduction speed, and improve neuropathy symptoms [15,16,17,39]. Here, TNF is linked to neuropathy.