In the study of the protective effect of Purendan ultramicro powder on retinopathy of STZ-induced glycosuria rats and its effect on the NF-κB signaling pathway, it was found that PRD may have a protective effect on the retina of diabetic rats by specifically blocking the AGEs/RAGE/NF-κB signaling pathway [17,18]. This evidence concerns the gene NFKB1 and retinal disorder.