In the study analyzing the effects of combined treatment of sagliptin on inflammatory factors and mononuclear cell PI3K-Akt pathway in elderly DN patients, it was also confirmed that the treatment of sagliptin can significantly reduce Hb A1c, 24 h UPro, and Cr in elderly DN patients, thus improving renal function [18,19]. The gene discussed is AKT1; the disease is liver dysplastic nodule.