In the study of regulating the renal inflammation in diabetic DN rats through the TLR4/NF-κB signaling pathway, it was also found that polydatin has a significant protective effect on the renal inflammation caused by DN, and its related mechanism may be related to regulating the TLR4/NF-κB signaling pathway and reducing the content of inflammatory factors in renal tissue [19,20]. This evidence concerns the gene TLR4 and liver dysplastic nodule.