In hyperglycemia, teneligliptin enhances HUVEC proliferation and inhibits HUVEC apoptosis by promoting B-cell lymphoma 2 (BCL2) expression, decreasing proapoptotic genes (BAX and CASP3), and expressing cell-cycle inhibitor hallmarks (P27, P21, and P53) (170). This evidence concerns the gene TP53 and Hyperglycemia.