NLRP3 and Hyperglycemia: Overexpression of SETD8 reduced inflammation by decreasing the activation of the NOD-like receptor pyrin domain 3 (NLRP3) inflammasome and the expression of microtubule-affinity regulating kinase 4 caused by hyperglycemia in human umbilical vein endothelial cells (HUVECs) (14, 15).