Glycolysis reprogramming is an essential component of cancer cells’ metabolic adaptation (Faubert et al., 2020; Paul et al., 2022), and it has been reported to be involved in the activation of key molecular pathways such as the PI3K/AKT/mTOR pathway (Deng et al., 2023; Malayil et al., 2023), and the HIF-1α pathway (Nagao et al., 2019; Kierans and Taylor, 2021) in tumor progression. Here, HIF1A is linked to cancer.