BIRC5 and central nervous system cancer: Wu et al. (2017) found that LINK-A lncRNA promotes glioma cell growth and invasion via the LINK-A/LDH-A axis, which enhances cell proliferation, migration, invasion, and glycolysis. This suggests that LINK-A’s involvement in metabolic reprogramming facilitates glioma cell growth and invasive properties. In a study by Hua et al. (2019), it was demonstrated that LINK-A lncRNA participates in glioma pathogenesis through the LINK-A/Survivin axis, leading to the suppression of cell apoptosis.