HIF1A and cancer: Zhang et al. (2019b) demonstrated that LINK-A expression is significantly elevated in OC, promoting cancer cell migration and invasion, and upregulating HIF1α, suggesting its involvement in metastasis. Similarly, Ma and Xue (2018) showed that LINK-A activates the TGF-β pathway to enhance migration and invasion in OC cells. In contrast, Filippov-Levy et al. (2020) observed a different aspect of LINK-A’s function in OC.