Zhao et al. (2019) found that LINK-A is significantly elevated in patients with metastatic osteosarcoma, promoting cancer cell migration and invasion, and upregulating HIF1α, a factor associated with metastasis. Kong et al. (2020) further revealed that LINK-A, along with TGF-β1, is upregulated in osteosarcoma patients and positively correlated with cancer cell migration, invasion, and stemness. Here, HIF1A is linked to osteosarcoma.