LINK-A mediates the activation of HIF1α by facilitating the recruitment and activation of BRK kinase, leading to the phosphorylation and stabilization of HIF1α, and HIF1α signaling plays a vital role in cancer cell adaptation to low oxygen levels (hypoxia) and tumor progression, contributing to glycolysis reprogramming, tumor growth and metastasis of TNBC(27). The gene discussed is HIF1A; the disease is neoplasm.