And LINK-A influences the glycolytic activity of cancer cells through various mechanisms, such as modulating the HIF1α signaling pathway in breast cancer (Filippov-Levy et al., 2020), interacting with the LDH-A in glioma (Wu et al., 2017), or affecting the Hexokinase-II in NSCLC(30). Here, LDHA is linked to central nervous system cancer.