Additionally, upregulated TF activities in MYOFIB/HSC were noted for PATZ1 in preneoplastic stages (e.g., Cirrhosis, AK, and CAG), while CEBPZ and SOX6 demonstrated elevated activities in malignant (e.g., cSCC and HCC) stages (Figure S2D, Table S3). The gene discussed is SOX6; the disease is hepatocellular carcinoma.