In addition, HLF and ARID5B were identified as TFs of Tregs in precancer stages (e.g., N_HPV, AAH, NEOLP, EOLP), while regulons such as FOXO1 and STAT5B were specifically detected in cancers (e.g., IDC, AIS, MIAC, IAC and PDAC). Here, FOXO1 is linked to cancer.