CXCR4 and neoplasm: It’s worth noting that these ligand-receptor interactions involved in wound repair after tissue damage (like CXCL12-CXCR4 axis), potentially exert a two-edged effect in regulating anti-tumor immune responses (e.g., Prostate-C14 and Oral cavity-C18) and promoting tumor cell growth (e.g., Prostate-C34 and Liver-C0, Fig. 5B, Figure S4A)27.