Last, we examined the bulk levels of ANXA1 RNA in TCGA data and observed a significant correlation of ANXA1 with CAF activation marker genes (FAP, ACTA2, COL6A3, MMP1 and TGF-β), wound healing-myCAF, ecm-myCAF, and TGFβ-myCAF gene signatures, as well as M2-like signatures of tumor-associated macrophages (TAMs) (Fig. 6F). Here, MMP1 is linked to neoplasm.