BRCA1 and esophageal squamous cell carcinoma: Similarly, for INMON, FOXO3 and IRF5 were common TFs in healthy and early-stage tissues (e.g., BRCA1-mut); specifically, PRDM4 was the TF in precancer stages (e.g., Goiters and HT) while ATF2 and RUNX1 were enriched in cancers (e.g., ESCC and IDC, Figure S2D, Table S3).