Similarly, for INMON, FOXO3 and IRF5 were common TFs in healthy and early-stage tissues (e.g., BRCA1-mut); specifically, PRDM4 was the TF in precancer stages (e.g., Goiters and HT) while ATF2 and RUNX1 were enriched in cancers (e.g., ESCC and IDC, Figure S2D, Table S3). Here, IRF5 is linked to esophageal squamous cell carcinoma.