Similarly, mutations in two genes driving neurodegenerative diseases, C9orf72 for Amyotrophic Lateral Syndrome (ALS) and NPC1 for Niemann-Pick Disease, impair STING degradation at the lysosome, inducing heightened or constitutive STING-dependent responses and resulting in disease20,21. Here, STING1 is linked to neurodegenerative disease.