To study tumor cell heterogeneity specifically in CRPC PRAD and NEPC samples and reasoning that lineage plasticity is likely driven by transcription factor (TF) networks, we focused on shared and unique gene–regulatory networks (GRNs) across samples using single–cell regulatory network inference (SCENIC), (Figure 2D, Supplementary Figure 4A–C, and Supplementary Table 5). This evidence concerns the gene TF and prostate adenocarcinoma.