Two GRNs, albeit comprising a smaller number of tumor cells, showed high activity for the TCF7L2 regulon (along with KLF8, FOXK1, FOXP2, BACH1) (labeled TCF7L2+) and CTCF (along with MAFG and NR1H) (labeled CTCF+) respectively (Figures 2D and Supplementary Table 6). Here, KLF8 is linked to neoplasm.