Specifically, YAP1 was high in PRAD/HGC but not NEPC (Figure 1C, P<1×10−4), while ASCL1 and other neuroendocrine–associated TFs were high in NEPC histologies but not PRAD/HGC (Figure 1D and Supplementary Figure 1C). Here, ASCL1 is linked to prostate adenocarcinoma.