IRF2 and neoplasm: By implementing SCENIC, we found nine tumor–associated GRNs within the PtR and PtRP GEMMs including one defined by Stat1/2 and Irf2/7/9, validating our recent findings on the critical role of JAK/STAT signaling in initiating plasticity (Figure 3A and 3B, Supplementary Figure 7, and Supplementary Table 8–9).