LRRK2 and Parkinson disease: Furthermore, when compared to GBA variants of PD, the phenotypically slower progression of disease at early stages in LRRK2-PD can be explained by the gain of functional connections found in central network cores (linking the cerebellum and putamen), which could compensate and provide robustness against early symptomatic expression in prodromal stages (Schindlbeck et al., 2019).