In a recent proteome wide association study of LRRK2 variants from the Parkinsons progression markers initiative cohort (PPMI) (Marek et al., 2018) the LRRK2 gene was directly linked to the regulation of several PD-associated proteins, many of which were subsequently identified as enriched in specific endolysosomal pathways, in microglial cells, and in immune response (Phillips et al., 2023). This evidence concerns the gene LRRK2 and Parkinson disease.