TGFB1 and muscle tissue disorder: It is well known that increased levels of TGF-β in skeletal muscle hamper myofiber regeneration and promote deposition of extracellular matrix components (ECM), which leads to a scar formation known as fibrosis in other muscular disorders (Wynn, 2008; Walton et al., 2017; Ismaeel et al., 2019).