In this regard, it has been shown that skeletal muscles of symptomatic ALS mice exhibit enhanced canonical TGF-β signaling, which correlates with ECM deposition and induction of fibro/adipogenic progenitors (FAPs) markers, a cell type responsible for secreting ECM (Gonzalez et al., 2017). Here, TGFB1 is linked to amyotrophic lateral sclerosis.