C/EBPβ overexpression inhibited the transcription of FOXO and REST genes by binding to their promoters, which not only makes GABAergic neurons more susceptible to degeneration during aging but also selectively induces the increased expression of LGMN in GABAergic neurons and increases the production of AEP in GABAergic neurons, which together lead to the aggravation of cognitive dysfunction in AD. This evidence concerns the gene CEBPB and Alzheimer disease.