Furthermore, C/EBPβ functions as a transcription factor for the calcium channel protein TRPC1, enhancing C/EBPβ‐TRPC1‐SOCE signaling, leading to ER stress and dysregulation of proteases and phosphatases, resulting in increased phosphorylated hTau and exacerbating AD's pathological progression.22 The gene discussed is TRPC1; the disease is Alzheimer disease.