In the validation cohort, after adjusting for tumor size, N stage, T stage, TNM stage, PNI, CEA, and chemotherapy variables, TD positivity retained prognostic value for CSS and OS rate (for CSS, HR: 1.75 (1.04–2.94); P = 0.035; for OS, 1.97 (1.21–3.18); P = 0.006; Table 4). Here, CEACAM5 is linked to neoplasm.