For instance, CAFs-derived SDF1 and CXCL14 can promote monocyte recruitment and trans-differentiation toward the TAM2, in turn, TAM2 can secrete SDF-1 and IL-6 to activate CAFs, further making up a positive loop that facilitates immunosuppression and prostate cancers progression [63, 64]. This evidence concerns the gene IL6 and Familial prostate cancer.