Conversely, RA-FLS transfected with miR-100-5p mimics exhibited reduced expression of TNF-α, IL-6, IL-8, MMP-1, and MMP-13 compared to RA-FLS transfected with NC mimics (all P < 0.05) (Figure S8A-E). The gene discussed is MMP13; the disease is rheumatoid arthritis.