Macrophages can take up extracellular lactate through monocarboxylate transporters, and lactate-driven p300/ cAMP response element-binding (CREB) protein-mediated acylation of HMGB1 promotes the release of HMGB1-containing exosomes from macrophages, leading to endothelial dysfunction [76]. The gene discussed is HMGB1; the disease is endothelial dysfunction.