Dietary intake of Rg3 in an an–imal model [0.123–10 mg25 Rg3/kg diet, 8 weeks] showed the reduction of body weight and fat content and improvement of hepatic steatosis by regulating proliferator-activated receptor gamma (PPARγ) and CCAAT/enhancer-binding protein alpha (C/EBPα) expression. The gene discussed is CEBPA; the disease is fatty liver disease.