Besides, Roux-en-Y gastric bypass (RYGB) has also been shown to prime NLRP6, through up-regulation of NLRP6 expression upon exposition of intestine cells to microbiota-related metabolites, taurine, and histamine, resulting from intestinal permeability due to obesity [254]. The gene discussed is NLRP6; the disease is obesity due to melanocortin 4 receptor deficiency.