Once the inflammatory process has cleared the infection, to maintain immune homeostasis and avoid detrimental effects, E3 ubiquitin ligase TRIM31 and dopamine directly bind to NLRP3 protein and attenuate NLRP3 inflammasome activation by promoting Lys-48-linked polyubiquitination and proteasomal degradation of oligomerized NLRP3 proteins [202, 203]. This evidence concerns the gene NLRP3 and infection.