Specifically, certain NLRP1 variants including NLRP1 rs12150220 polymorphism, found in skin inflammatory diseases, such as vitiligo-associated autoimmune diseases, like Addison’s disease, type 1 diabetes, and systemic lupus erythematous, have been associated with a decreased occurrence risk of these diseases [40]. Here, NLRP1 is linked to primary adrenal insufficiency.