However, in the in-vivo infection model, NLRP12 and NLRP3 inflammasomes are concomitantly required to provide an anti-infectious resistance against Yersinia pestis, which suggests that in some infection setups, activation of divers NLRP family proteins or NLRP inflammasomes might provide an optimal protection again microbial antigens [306]. This evidence concerns the gene NLRP12 and infection.