Specifically, this aberrant activation of NLRP1 inflammasome have been associated with mutations found in NLRP1, which in turn have mainly been associated with occurrence of diseases, including severe chronic obstructive pulmonary disease (COPD) [93], systemic lupus erythematosus [94], type 1 diabetes [95], vitiligo-associated autoimmune diseases [20, 55, 96, 97], inflammatory bowel disease [98], arthritis, dyskeratosis, psoriasis, multiple self-healing palmoplantar carcinomas (MSPCs) and familial keratosis lichenoides chronica (FKLC) [43, 99] (Table 1). The gene discussed is NLRP1; the disease is Corneal intraepithelial dyskeratosis with palmoplantar hyperkeratosis and laryngeal dyskeratosis.