The gain-of-function mutation(s) within Nlrp3 gene have been the first cause of NLRP3 inflammasome dysregulation and associated with inflammatory disorders, one of which being CAPS, a rare condition covering familial cold autoinflammatory syndrome (FCAS, MIM 120100), also known as familial cold urticaria (FCU), Muckle–Wells syndrome (MWS), and neonatal onset multi-systemic inflammatory disease (NOMID) [216]. The gene discussed is NLRP3; the disease is familial cold autoinflammatory syndrome.