In the same way, the nondeletional types of α-thalassemia caused by single gene mutations, such as Hb Constant Spring (Hb CS, c.427 T > C), Hb Quong Sze (Hb QS, c.377 T > C) and Hb Westmead (Hb WS, c.369 C > G), could be theoretically corrected by base editors in HSCs. The gene discussed is GSTM1; the disease is thalassemia.