PKNOX2 and heart failure: In vitro experiments confirmed PKNOX2 effects in pathological myocardial fibrosis, through generating PKNOX2 overexpression and fibroblast-specific knockout mouse line, we found that PKNOX2 knockout aggravated cardiac disfunction and exacerbated cardiac fibrosis, while PKNOX2 overexpression had an opposite effect in TAC induced heart failure mice.