In the transcriptome analysis (GSE110209) of an acute myocardial infarction (AMI) murine model,26Sox5 expression was significantly increased in the border zone after 14 days post-AMI (Fig. 2g) and was validated by immunofluorescence (Fig. 2h, i, Supplementary Table S5, 6), which was positively correlated with Pcsk5, the marker gene of arteriole vessels (Fig. 2j). This evidence concerns the gene PCSK5 and acute myocardial infarction.