We further validated these TFs in an independent bulk transcriptome dataset (GSE145154) previously published by our group that contains data for 15 normal donors and 52 transplanted failing hearts.7 The results indicated that MEOX1 was highly expressed in the context of heart failure, whereas PKNOX2 was not increased in bulk RNA profiling, suggesting a different pathogenic role of PKNOX2 (Fig. 4j). The gene discussed is PKNOX2; the disease is heart failure.