In the transcriptome analysis (GSE110209) of an acute myocardial infarction (AMI) murine model,26Sox5 expression was significantly increased in the border zone after 14 days post-AMI (Fig. 2g) and was validated by immunofluorescence (Fig. 2h, i, Supplementary Table S5, 6), which was positively correlated with Pcsk5, the marker gene of arteriole vessels (Fig. 2j). Here, PCSK5 is linked to myocardial infarction.