The abundance of HP protein (per 1 SD increase) was associated with higher ALM (beta: 0.012, 95% CI: 0.007–0.018, P = 1.2*10−5) and higher grip strength (OR: 0.96, 95% CI: 0.94–0.98, P = 4.2*10−5), indicating the reduced risk of sarcopenia. The gene discussed is HP; the disease is sarcopenia.