Based on the Health Professionals Follow-up Study, Petimar et al recently revealed that metabolic and inflammatory biomarkers jointly mediated the associations of BMI and adult weight gain with the risk of CRC in men, with stronger results for metabolic biomarkers such as adiponectin, C-peptide, and soluble leptin receptors.41 Interestingly, leptin and soluble leptin receptors may have been mediators in all three previous studies. Here, LEP is linked to colorectal carcinoma.