By contrast, individuals with BMIs of 25.0–27.4 kg/m2 (risk ratio 1.29; 95% confidence interval, 0.98–1.69) and ≥27.5 kg/m2 (risk ratio 1.28; 95% confidence interval, 0.98–1.68) had a higher risk of CRC due to indirect effects of circulating leptin and adiponectin. This evidence concerns the gene LEP and colorectal carcinoma.