After adjusting for confounding factors, including age, sex, DM, BMI, eGFR, albumin, UPCR, pulse pressure, ABI and VRI, multivariate analysis revealed that age (odds ratio [OR]: 1.12; 95% confidence interval [CI]: 1.08–1.16; P < 0.001), BMI (OR: 0.68; 95% CI: 0.61–0.77; P < 0.001), average ABI (OR: 0.81/0.1 increase; 95% CI: 0.67–0.98; P = 0.032) and VRI (OR: 0.93/0.1 increase; 95% CI: 0.88–0.98; P = 0.010) were independently associated with sarcopenia. This evidence concerns the gene ALB and sarcopenia.