Single genes were mapped to 3 risk loci, hence these represent bona fide candidates to be causative of the observed associations at respective loci: BMAL1 (basic helix-loop-helix ARNT Like 1) at the new rs2035380 locus for IBS, ADCY2 (adenylate cyclase 2) at the rs6899057 locus in common for IBS and IBS-M, and DOCK9 (dedicator of cytokinesis 9) at the rs9517497 locus for IBS (Table 1). The gene discussed is ADCY2; the disease is irritable bowel syndrome.