Similar to the results obtained from genetic correlations, these analyses revealed the 2 novel risk loci, tagged by rs2048419 (CLDN23/MFHAS1) and rs2035380 (BMAL1), had both been previously associated with multiple traits including cardiovascular (hypertension, coronary artery disease), psychiatric (anxiety-like), and metabolic (body mass index) traits (Figure 6). The gene discussed is CLDN23; the disease is coronary artery disorder.