BMAL1 and irritable bowel syndrome: The 2 novel IBS risk loci identified here, led by rs2035380 on chromosome 11 (for IBS) and rs2048419 on chromosome 8 (for IBS-M), had been previously linked to hypertension, diastolic/systolic BP, and coronary artery disease (as per results publicly available in PhenoScanner and GWAS Atlas).30, 31, 32, 33 Although multiple genes were mapped to the rs2048419 locus, only 1, BMAL1, is associated with rs2035380.