This can result in increased cell turnover, which in turn leads to the accumulation of further genetic changes favoring neoplastic cell transformation.45 Unsurprisingly, infection with cagA-positive strains markedly increases the risk of gastric cancer.46CagA-positive strains are responsible for 60% of H. pylori infections in individuals worldwide.47,48,49 Strains isolated in East Asian countries such as Japan, China, and Korea are almost all CagA-positive.50 Furthermore, CagA protein can be divided into the Western-type CagA and East Asian-type CagA. This evidence concerns the gene S100A8 and infection.