Therefore, it is crucial to unravel expression levels and the diagnostic value of serum NLRP3, MMP‐9 and IFN‐γ in patients with hydrocephalus and intracranial infections after craniotomy, which will provide a reference for further clarifying the pathogenesis of hydrocephalus and intracranial infection, as well as new ideas for clinical prediction and management of hydrocephalus and intracranial infection. This evidence concerns the gene NLRP3 and Hydrocephalus.