Similarly, the AUC of the combination of serum NLRP3, MMP‐9 and IFN‐γ for the diagnosis of hydrocephalus was 0.957 (Figure 2i), and the diagnostic efficacy of the combination of the three for hydrocephalus was higher than the diagnostic efficacy of NLRP3, MMP‐9 or IFN‐γ alone (Figure 2j). This evidence concerns the gene NLRP3 and Hydrocephalus.