Conversely, high-dose VC obviously decreased phosphorylated PI3K, AKT (except 1 days) and mTOR in CLP-induced sepsis rat cardiomyocytes at three points in time (p < 0.05), but it did not affect the phosphorylation of PI3K and AKT at 1 day. The gene discussed is MTOR; the disease is Sepsis.