Our study was consistent with that, the levels of p-JNK, p-Erk1/2, p-P38, p-NF-κB and p-IKK α/β were higher in sepsis and SIMI, indicating that MAPK and NF-κB were activated, while high-dose VC reversed their phosphorylation. The gene discussed is NFKB1; the disease is Sepsis.