LPS – lipopolysaccharide, BMI – body mass index, AF – atrial fibrillation, CHA2DS2-VASc and HAS-BLED – stroke risk score and bleeding risk score (see ref. 11), CKD – chronic kidney disease, COPD – chronic obstructive pulmonary disease, PCI – percutaneous coronary intervention, CABG – coronary artery by-pass grafting, MI – myocardial infarction, TIA – transient ischemic attack, RAA – renin-angiotensin-aldosterone, ASA – acetylsalicylic acid, NSAID – non-steroidal anti-inflammatory drug, CCA – calcium channel antagonist. Here, REN is linked to atrial fibrillation.