Overall, significant differences were observed in N stage (p = 0.024), histologic grade (p < 0.001), level of tumor-infiltrating lymphocytes (p < 0.001), molecular subtype (p < 0.001), ER status (p < 0.001), PR status (p < 0.001), and Ki-67 proliferation index (p < 0.001) according to HER2 status. This evidence concerns the gene ESR1 and neoplasm.