Using flow cytometry, the levels of IL-22+, IL-10R2+ or IL-22R1+ cells in PBMCs from PDAC patients were compared to controls and patients with other disorders, including AP, CP, alcohol-induced acute pancreatitis (AIAP), cholangitis (Cho), common bile duct stone (CBDS) and gall bladder stone (GBS). Here, IL22 is linked to cholangitis.