We established a murine pancreatic cancer model by orthotopically injecting Pan02 cells into C57BL/6 mice to verify whether the population of IL-10R2+/IL-22R1+ myeloid cells was augmented in a PDAC murine model in a similar manner to human PDAC patients (Fig. 3a) [40, 41]. This evidence concerns the gene IL10RB and familial pancreatic carcinoma.