Along with these risk factors, intrinsic genetic, transcriptional and post-translational changes such as the expression and/or function of Fanconi Anaemia Complementation Group (FANC) [4], Grainyhead-like 3 (GRHL3) [5], Filaggrin (FLG) [6], and cellular localisation of Y-box binding protein 1 (YBX1) [7] impact HNSCC development. Here, FLG is linked to Fanconi anemia.