The following changes in circulating sex steroids between MLWH with and without ALM/W-sarcopenia were found: serum total T (p = 0.001) and cFT (p < 0.001) were significantly lower in sarcopenic than non-sarcopenic MLWH while other sex hormones and SHBG did not differ between the two groups. The gene discussed is SHBG; the disease is sarcopenia.