Also, when AML cells are treated with 8CA/8AA, methionine depletion induces higher apoptosis and saturating cells with external SAM rescues the survival of AML cells, suggesting the antileukemic effect of 8CA/8AA could be enhanced when combined with methionine depletion, and 8CA/8AA could function on AML cells through impairing the synthesis of SAM by downregulating MAT2A (Supplementary Fig. 3D–G). The gene discussed is MAT2A; the disease is acute myeloid leukemia.