Notably, a different endothelial binding protein, VCAM1 (vascular cell adhesion molecule 1), which binds to the integrin VLA4 (very late antigen 4 α4β1) and has been implicated in regulating ALL chemotherapy resistance18,20, was found to not correlate with disease state (Supplemental Fig. 4). The gene discussed is VCAM1; the disease is acute lymphoblastic leukemia.