Finally, four novel cataract loci, including Casz1, Gstm2, Krtp2-Dpm3-Efna1 and Sema4d, identified by recent human GWAS studies [80], are also shown in Additional file 6, Figs. S28-31, that might help in the interpretation of non-coding variants if found in evolutionarily conserved distal regions marked by looping anchors. The gene discussed is EFNA1; the disease is cataract.