In this study, we first revealed ZFP36 protein expression were downregulated in DKD kidney tissues and in podocyte MPC5 and mesangial SV40-MES-13 cells after HG stimulation,while the downregulation of ZFP36 can trigger the activation of ferritinophagy and the initiation of ferroptosis [43].CD44, a cell-surface glycoprotein, has been extensively researched, with its functions encompassing a wide range of physiological and pathological activities, such as cell proliferation, adhesion, migration, angiogenesis, inflammation, and cytoskeleton rearrangement [44]. This evidence concerns the gene ZFP36 and diabetic kidney disease.