In addition, IHC results showed that compared with m/m mice, the expression of CD44 and TFR1 in db/db mice was significantly increased, and the expression of ZFP36 and GPX4 was significantly reduced (Fig. 9A).Similar findings were also observed in renal tissue from DKD patients compared with MCD patients(Fig. 9B). The gene discussed is GPX4; the disease is diabetic kidney disease.