Of note, the deletion of CTCF binding sites was not found in 39 French patients presenting lone sinus node defects (n = 11), or with other electrical cardiac defect (n = 28) nor in 10,994 atrial fibrillation cases from the TOPMed-CCDG dataset with structural variant data35 (Supplementary Data 10). The gene discussed is CTCF; the disease is atrial fibrillation.