CD6 and diabetes mellitus: After multivariable adjustment (see “ Methods”), we found 18 out of 74 proteins associated with prevalent diabetes (FDR-q < 0.1), with inverse associations for T cell surface glycoprotein CD6 isoform (CD6), C-X-C motif chemokine 10 (CXCL10), and tumor necrosis factor (ligand) superfamily, member 12 (TWEAK), and positive associations for the remaining 15 proteins (Fig.2A).