LCAs derived from adenocarcinomas (ACs) of different patients maintained the intertumoral heterogeneity of cancer cell differentiation degree, and the expression patterns of EpCAM, cytokeratin 7 (CK7) and Ki67 were also retained in the LCAs (Fig. 3b, Supplementary Fig. 4a, b). This evidence concerns the gene MKI67 and adenocarcinoma.