The combined drug treatment assay demonstrated that a CAF-targeted drug (pirfenidone, PFD) significantly enhanced the sensitivity of LC22 cancer cells to Taxol (Fig. 6g) and caused more apoptotic as well as dead EpCAM+/E-cadherin+ cancer cells (Fig. 6h, i, Supplementary Fig. 8e). Here, EPCAM is linked to cancer.