A recent report described a focal positivity for Desmin and SMA in two ASPS that unexpectedly harboured non-canonical translocation of TFE3 with HNRNPH3, DVL2 or PRCC, the latter two being previously described in renal cell carcinoma and PEComa [19]. This evidence concerns the gene TFE3 and neoplasm with perivascular epithelioid cell differentiation.