In both in vitro and in vivo models of CVB3-induced VMC, we discovered that suppressing miR-29b-3p expression obviously weakened the upregulation and activation of NLRP3 inflammasomes (including NLRP3, ASC, and caspase-1), as demonstrated by the decreasing level of inflammatory mediator IL-1β. Here, CASP1 is linked to liver mesenchymal hamartoma.