In the present study, it was observed that N-HDL, ApoB, APTT, and PLT in lipid metabolism and coagulation indices in different etiologic groups were risk factors for disease progression of NONFH, whereas LDL might be a protective factor for NONFH progression.NONFH patients with abnormal blood hypercoagulability and dyslipidemia should be taken seriously in clinical practice and disease progression should be considered. This evidence concerns the gene APOB and metabolic syndrome.