NT-proBNP levels showed a direct correlation with age (r = 0.25, p = 0.002), total number of pulmonary B-lines (r = 0.18, p = 0.025), pleural effusion extension (r = 0.26, p = 0.001), and positivity of the Framingham HF criteria (r = 0.14, p = 0.026). This evidence concerns the gene NPPB and Pleural effusion.