According to the ROCs, NT-proBNP levels (AUC 0.63, p = 0.039), pulmonary B-lines (AUC 0.77, p = 0.001) and pleural effusion extension (AUC 0.67, p = 0.005) can predict HFrEF (vs non-HFrEF). This evidence concerns the gene NPPB and Pleural effusion.