The regulatory role of these two miRs on the expression of KCNN3 mRNA was confirmed through the use of miR-499 and miR-208 mimics as shown in Fig. 1H. Consistent with all these results, a significant inverse correlation between AGPS and miR-499/miR-208, KCNN3 and miR-499/miR-208 was observed in invasive breast carcinoma tissues (cohort 3) (Fig. 1I). This evidence concerns the gene KCNN3 and invasive breast carcinoma.