INS and diabetes mellitus: The metabolic characterisation of three patients with one rare lipodystrophic syndrome, namely neutral lipid storage disease with myopathy, due to homozygosity for loss-of-function mutations in the ATGL gene, highlighted the consistent significant increase in pancreatic fat and visceral fat in these conditions, with subsequent impaired insulin response to glucose (Natali et al. 2013).The relationship between lipodystrophy and diabetes underscores the crucial role of AT homeostasis in maintaining metabolic health.