INS and diabetes mellitus: Metabolically-activated AT macrophages are polarised into a pseudo-proinflammatory phenotype, secreting proinflammatory cytokines, such as TNF-α, IL-5, IL-1 and NO, capable of impairing insulin signaling in the AT and indirectly predisposing to diabetes (Kratz et al. 2014, Russo & Lumeng 2018).