LEP and obesity due to melanocortin 4 receptor deficiency: The secretion pattern of adipokines is dependent on body fat distribution and mass, with obesity being associated with increased production of proinflammatory mediators, such as TNF-alfa, leptin, IL-6, IL-12, IL-18 and the chemokines IL-8 and CCL2/MCP-1, rather than anti-inflammatory adipokines like adiponectin or omentin (Mancuso 2016).