SLC5A8 and neoplasm: The apical iodide transporter (SLC5A8) and the sodium–iodide symporter (SLC5A5) gene expression was characterized by a 2.5-fold and a 2.4-fold upregulation of normalized expression values in the TERT-negative compared to TERT-positive tumor, respectively, whereas Pendrin (SLC5A8) showed increased expression (Fig. 8).