Multiple-organ, multifocal leiomyomas are rare and may represent either independent primaries (sharing a common etiology such as EBV infection in the immunocompromised patients or an inherited causal gene mutation such as FH inactivation in the HLRCC syndrome context), or they are considered metastases originating from benign uterine leiomyoma [10]. This evidence concerns the gene FH and Epstein-Barr virus infection.