For example, copper chelation downregulates transcriptomic expression of EMT markers and transcription factors in cancer cell lines (Poursani et al. 2023), or copper chelation therapy inhibited GSK3B phosphorylation and in turn induced downregulation of PD-L1 and increased anti-cancer immune response (Rouaen et al. 2022; Voli et al. 2020). This evidence concerns the gene CD274 and cancer.