According to our findings, cancer patients with low expression of MAP1LC3A, SNCA, and MAPT and high expression of CDK1, AP1S1, CASP3, TMPRSS6, and GSK3B have poor overall survival while patients with high expression of MAP1LC3A, SNCA, and MAPT and low expression of CDK1, AP1S1, CASP3, TMPRSS6, and GSK3B have good overall survival. The gene discussed is AP1S1; the disease is cancer.