TMPRSS6 and cancer: As a result, the pan-cancer signature included 8 genes CDK1, AP1S1, CASP3, MAP1LC3A, SNCA, TMPRSS6, MAPT, and GSK3B, and the LGG signature included 3 genes CDK1, CASP3, and ALB. It is understandable that the pan-cancer signature does not include all the genes of the LGG signature, because some genes may play critical roles in a specific cancer type such as LGG but in the context of pan-cancer, they may not be as important as other genes.