But according to the consistent increasing trend of cytokines and the level of CD8+ T cells in PBMC (Supplementary Figs. 4, 5) after first cycle of RAK infusion, we cannot exclude the contribution of the infusion to the hyperinflammatory state, which might be one of underlying factors associated with his acute myocardial infarction. The gene discussed is CD8A; the disease is acute myocardial infarction.