CAT and diabetic neuropathy: An interesting finding in our study was the antioxidant effect of pregabalin, which showed that perhaps one of the therapeutic mechanisms of pregabalin in the treatment of painful diabetic neuropathy is its antioxidant effect, which has already been shown in animal studies with increased catalase and glutathione peroxidase [29, 30], but no human study of this pregabalin mechanism had been performed.