HOXC8 and intrahepatic cholangiocarcinoma: Nude mouse xenografts were generated to reveal how circSLCO1B3 affects ICC growth in vivo. HuCCT1 cells were subcutaneously injected into BALB/c nude mice aged 4 weeks with empty vector (NC group) or overexpression plasmid targeting circSLCO1B3 (oe-circSLCO1B3 group) or oe-circSLCO1B3+ HOXC8 shRNA lentiviral plasmid (oe-circSLCO1B3+sh-HOXC8) (Fig. 7a).