With tumor progression, the proportions of cells exerting antitumor immune responses, including CD8+ T cells (P < 0.001), NK cells (P < 0.001), and M1-type macrophages (P < 0.05), were significantly reduced at 28 days compared with mice at 0 day or 7 days, while the proportion of MDSCs, which promoted tumor progression, was significantly increased (P < 0.05), and Treg also showed an increasing trend (P > 0.05) (Fig. 2A–G). This evidence concerns the gene CD8A and neoplasm.