WB results (Fig. 6C–J) showed that combined immunotherapy with LM∆E6E7 and LI∆E6E7 significantly decreased the phosphorylation levels of the JAK1-STAT1 and JAK2-STAT3 pathways in tumor tissues, and the expression of downstream regulatory genes was also altered (Additional file 1: Table S1, Fig. S1). This evidence concerns the gene STAT3 and neoplasm.