STAT3 and neoplasm: These results suggest that the immunosuppressive status induced by tumor progression was conducive to the generation of MDSCs, but immunotherapy with the LM∆E6E7 and LI∆E6E7 combination inhibited this situation by decreasing the expression of MDSCs inducible factors and downregulating the phosphorylation level of STAT3 protein, thus inhibiting the differentiation and expansion of MDSCs in vivo.