At the same time, the immune cell analysis in tumor infiltrating lymphocytes (TILs) (28 days) also showed that compared with the PBS or LM∆ and LI∆ group, the proportions of CD8+ T cells (P < 0.001) and M1-type macrophages (P < 0.05) and the M1/M2 ratio (P < 0.001) were significantly higher in the E6E7 group mice, and simultaneously, the proportion of MDSCs (P < 0.05) was significantly lower (Fig. 2O–R, T). Here, CD8A is linked to neoplasm.