OPTN and amyotrophic lateral sclerosis: Of those genes, 12 have previously been associated with ALS and/or FTLD, including C9orf72 (FDR = 3.65E-09; Fig. 1d), CDH22 (FDR = 2.28E-05), TARDBP (FDR = 0.011), CAMTA1 (FDR = 0.034), FUS (FDR = 0.042), and OPTN (FDR = 0.046).